ea0077oc5.5 | Bone and Calcium | SFEBES2021
Goldsworthy Michelle
, Lovegrove Catherine
, Moir Lee
, Wiberg Akira
, Turney Benjamin
, Furniss Dominic
, Hannan Fadil
, Thakker Rajesh
, Howles Sarah
Diacylglycerol kinase delta (DGKD) has been implicated in calcium homeostasis and nephrolithiasis by genome-wide association studies. We have previously demonstrated that alterations in expression of DGKD cause biased calcium-sensing receptor (CaSR) signalling in vitro. To further elucidate the physiological role of DGKD we examined the biochemical phenotype of a Dgkd-haploinsufficient (+/-) mutant mouse developed by the International Mouse Phenotyping Consor...